- 文献引用 : 4
|Application ||WB, IHC-P-Leica, E|
|Other Names||Hematopoietic progenitor cell antigen CD34, CD34, CD34|
|Target/Specificity||This CD34 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 185-214 amino acids from the Central region of human CD34.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues|
Author : Zheng X1,Ma W1,Sun R1,Yin H2,Lin F3,Liu Y1,Xu W4,Zeng H5.
Redox Biol. 2017 Sep 22;14:237-249. doi: 10.1016/j.redox.2017.09.014. [Epub ahead of print]
Author : Yang L1,Yang Z2,Li D3,Liu Z2,Zou Q4,Yuan Y4,Xu H5.
Pathol Oncol Res. 2017 Sep 18. doi: 10.1007/s12253-017-0284-5. [Epub ahead of print]
Author : Wang L, Huang X, Zheng X, Wang X, Li S, Zhang L, Yang Z.
Clin Transl Oncol. 2013 Oct 9. [Epub ahead of print]
Author : Liu Y, Wang Z, Kwong SQ, Lui EL, Friedman SL, Li FR, Lam RW, Zhang GC, Zhang H, Ye T.
J Hepatol. 2011 Sep;55(3):612-25. doi: 10.1016/j.jhep.2010.11.035. Epub 2011 Jan 18.
Provided below are standard protocols that you may find useful for product applications.
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M, et al. Hum Mol Genet, 2010 Oct 1. PMID 20639392. The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms. Cho SY, et al. Cancer Res, 2010 Apr 15. PMID 20388788. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells. Stellos K, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20378847. Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3. Artico M, et al. Eur J Histochem, 2010 Mar 11. PMID 20353905.