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ALDH6A1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 3 - ALDH6A1 Antibody AM1838b
    Fluorescent image of MCF-7 cells stained with ALDH6A1 Antibody (Cat#AM1838b). AM1838b was diluted at 1:25 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
  • 14 - ALDH6A1 Antibody AM1838b
    Immunohistochemical analysis of paraffin-embedded H.colon section using ALDH6A1 Antibody(Cat#AM1838b). AM1838b was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 1 - ALDH6A1 Antibody AM1838b
    Western blot analysis of lysates from MCF-7, T47D cell line (from left to right), using ALDH6A1 Antibody(Cat. #AM1838b). AM1838b was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20μg per lane.
  • 14 - ALDH6A1 Antibody AM1838b
    Immunohistochemical analysis of paraffin-embedded H.liver section using ALDH6A1 Antibody(Cat#AM1838b). AM1838b was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, IF, WB, E
Primary Accession Q02252
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,IgK
Clone Names 147CT8.3.4
Calculated MW 57840 Da
Additional info
Gene ID 4329
Other Names Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, MMSDH, Malonate-semialdehyde dehydrogenase [acylating], Aldehyde dehydrogenase family 6 member A1, ALDH6A1, MMSDH
Target/Specificity This ALDH6A1 antibody is generated from mouse immunized with ALDH6A1 recombinant protein.
Dilution IF~~1:25
IHC-P~~1:25
WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH6A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH6A1
Synonyms MMSDH
Function Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Cellular Location Mitochondrion.
Research Areas

BACKGROUND

This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

REFERENCES

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.
Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34. Kuiper H, et al. Cytogenet Genome Res, 2005. PMID 15909363.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
The human plasma proteome: a nonredundant list developed by combination of four separate sources. Anderson NL, et al. Mol Cell Proteomics, 2004 Apr. PMID 14718574.

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