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CDCA8 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CDCA8 Antibody AM1868b
    CDCA8 Antibody (Cat. #AM1868b) western blot analysis in U251 cell line lysates (35μg/lane).This demonstrates the CDCA8 antibody detected the CDCA8 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q53HL2
Other Accession NP_060571.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 181CT41.2.3
Calculated MW 31323 Da
Additional info
Gene ID 55143
Other Names Borealin, Cell division cycle-associated protein 8, Dasra-B, hDasra-B, Pluripotent embryonic stem cell-related gene 3 protein, CDCA8, PESCRG3
Target/Specificity This CDCA8 monoclonal antibody is generated from mouse immunized with CDCA8 recombinant protein.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDCA8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDCA8
Synonyms PESCRG3
Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment- error-correction and chromosome alignment.
Cellular Location Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.
Research Areas

BACKGROUND

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004 [PubMed 15249581]).

REFERENCES

Bourhis, E., et al. Biochemistry 48(29):6783-6793(2009)
Zhang, Q., et al. Mol. Biol. Rep. 36(3):603-609(2009)
Klein, U.R., et al. Mol. Biol. Cell 20(1):410-418(2009)
Xia, F., et al. Mol. Cell. Biol. 28(17):5299-5311(2008)
Jelluma, N., et al. Cell 132(2):233-246(2008)

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