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MAP3K11 Antibody (ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - MAP3K11 Antibody (ascites) AM1906a
    MAP3K11 (Cat. #AM1906a) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the MAP3K11 antibody detected the MAP3K11 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q16584
Other Accession NP_002410.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 230CT5.3.1
Calculated MW 92688 Da
Additional info
Gene ID 4296
Other Names Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850)
Target/Specificity This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein.
Dilution WB~~1:100~500
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP3K11 Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K11 (HGNC:6850)
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent
Tissue Location Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

REFERENCES

Chen, J., et al. Oncogene 29(31):4399-4411(2010)
Liou, G.Y., et al. Biochem. J. 427(3):435-443(2010)
Mishra, P., et al. Mol. Endocrinol. 24(3):598-607(2010)
Rangasamy, V., et al. Cancer Res. 70(4):1731-1740(2010)
Velho, S., et al. Hum. Mol. Genet. 19(4):697-706(2010)

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