|Application ||IF, IHC-P, WB, E|
|Other Accession||P23565, P46660, Q08DH7, NP_116116.1|
|Other Names||Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, NF-66, Neurofilament-66, Neurofilament 5, INA, NEF5|
|Target/Specificity||This INA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from human INA.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.|
|Tissue Location||Found predominantly in adult CNS.|
Provided below are standard protocols that you may find useful for product applications.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
Leermakers, F.A., et al. Eur. Biophys. J. 39(9):1323-1334(2010)
Martins-de-Souza, D., et al. J Psychiatr Res 43(11):978-986(2009)
Ducray, F., et al. Neurology 72(2):156-161(2009)
Willoughby, V., et al. Appl. Immunohistochem. Mol. Morphol. 16(4):344-348(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)