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GSN Antibody (N-term)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - GSN Antibody (N-term) AM1936b
    Anti-GSN Antibody (N-term)at 1:1000 dilution + Ramos whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 86 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - GSN Antibody (N-term) AM1936b
    GSN Antibody (N-term) (Cat. #AM1936b) western blot analysis in MDA-MB435 cell line lysates (35μg/lane).This demonstrates the GSN antibody detected the GSN protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P06396
Other Accession Q3SX14, NP_000168.1
Reactivity Human
Predicted Bovine
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 328CT2.2.1
Calculated MW 85698 Da
Additional info
Gene ID 2934
Other Names Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
Target/Specificity This GSN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 230-259 amino acids from the N-terminal region of human GSN.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSN
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular Location Isoform 2: Cytoplasm, cytoskeleton.
Tissue Location Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
Research Areas

BACKGROUND

The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

REFERENCES

Pottiez, G., et al. Rapid Commun. Mass Spectrom. 24(17):2620-2624(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lee, P.S., et al. Blood Purif. 29(2):99-101(2010)
Solomon, J.P., et al. Biochemistry 48(48):11370-11380(2009)
Litwin, M., et al. Acta Biochim. Pol. 56(4):739-743(2009)

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