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RAT Camk2a Antibody (ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - RAT Camk2a Antibody (ascites) AM2002a
    RAT Camk2a Antibody (Cat. #AM2002a) western blot analysis in rat brain tissue lysates (35μg/lane).This demonstrates the Camk2a antibody detected the Camk2a protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P11275
Other Accession P11798, NP_037052.1
Reactivity Rat
Predicted Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 390CT12.4.4
Calculated MW 54115 Da
Additional info
Gene ID 25400
Other Names Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a
Target/Specificity Purified His-tagged Camk2a protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:1000~8000
Format Rat monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAT Camk2a Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Camk2a
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).
Cellular Location Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts
Research Areas

BACKGROUND

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

REFERENCES

Hund, T.J., et al. J. Clin. Invest. 120(10):3508-3519(2010) Xu, L., et al. Circ. Res. 107(3):398-407(2010) Guetg, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13924-13929(2010) Blaich, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10285-10289(2010) Jenkins, M.A., et al. J. Neurosci. 30(15):5125-5135(2010)

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