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STK39 Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - STK39 Antibody(Ascites) AM2027a
    STK39 Antibody (Cat. #AM2027a) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the STK39 antibody detected the STK39 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9UEW8
Other Accession O88506, Q9Z1W9, NP_037365.2
Reactivity Human
Predicted Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 430CT4.4.1
Calculated MW 59474 Da
Additional info
Gene ID 27347
Other Names STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, DCHT, Serine/threonine-protein kinase 39, STK39, SPAK
Target/Specificity Purified His-tagged STK39 protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:1000~4000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTK39 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK39
Synonyms SPAK
Function May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
Cellular Location Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved.
Tissue Location Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis
Research Areas

BACKGROUND

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq].

REFERENCES

Duarte, J.D., et al. Pharmacogenet. Genomics 20(8):516-519(2010)
Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Balatoni, C.E., et al. Am. J. Pathol. 175(4):1653-1661(2009)
Cunnington, M.S., et al. BMC Med. Genet. 10, 135 (2009) :

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