|Application ||WB, E|
|Calculated MW||25039 Da|
|Other Names||C-reactive protein, C-reactive protein(1-205), CRP, PTX1|
|Target/Specificity||This CRP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from human CRP.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.|
|Tissue Location||Found in plasma.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
Brindle, E., et al. J. Immunol. Methods 362 (1-2), 112-120 (2010) :
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Marott, S.C., et al. J. Am. Coll. Cardiol. 56(10):789-795(2010)
Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :
Kuhlenbaeumer, G., et al. Cerebrovasc. Dis. 30(5):476-482(2010)