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CRP Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CRP Antibody AM2041b
    CRP Antibody (Cat. #AM2041b) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the CRP antibody detected the CRP protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P02741
Other Accession NP_000558.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names 506CT15.5.3
Calculated MW 25039 Da
Additional info
Gene ID 1401
Other Names C-reactive protein, C-reactive protein(1-205), CRP, PTX1
Target/Specificity This CRP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from human CRP.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRP
Synonyms PTX1
Function Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cellular Location Secreted.
Tissue Location Found in plasma.
Research Areas

BACKGROUND

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.

REFERENCES

Brindle, E., et al. J. Immunol. Methods 362 (1-2), 112-120 (2010) :
Lim, L.S., et al. Invest. Ophthalmol. Vis. Sci. 51(9):4458-4463(2010)
Marott, S.C., et al. J. Am. Coll. Cardiol. 56(10):789-795(2010)
Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :
Kuhlenbaeumer, G., et al. Cerebrovasc. Dis. 30(5):476-482(2010)

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