注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   心血管   >   SERPINC1 Antibody (Ascites)   

SERPINC1 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - SERPINC1 Antibody (Ascites) AM2053a
    SERPINC1 Antibody (Cat. #AM2053a) western blot analysis in rat liver tissue lysates (35μg/lane).This demonstrates the SERPINC1 antibody detected the SERPINC1 protein (arrow).
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01008
Other Accession NP_000479.1
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 435CT4.7.4
Additional info
Gene ID 462
Other Names Antithrombin-III, ATIII, Serpin C1, SERPINC1, AT3
Target/Specificity This SERPINC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from human SERPINC1.
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSERPINC1 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINC1
Synonyms AT3
Function Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Cellular Location Secreted, extracellular space.
Tissue Location Found in plasma.
Research Areas

BACKGROUND

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

REFERENCES

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zhang, G.S., et al. Blood Coagul. Fibrinolysis 21(6):588-591(2010)
Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
Picard, V., et al. Biochemistry 34(26):8433-8440(1995)

FeedBack

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-88856768 tech-china@abcepta.com.


我要评价