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MX1 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - MX1 Antibody AM2061b
    MX1 Antibody (Cat. #AM2061b) western blot analysis in T47D cell line lysates (35μg/lane).This demonstrates the MX1 antibody detected the MX1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P20591
Other Accession P27594, NP_001138397.1
Reactivity Human
Predicted Pig
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 474CT4.1.5
Calculated MW 75520 Da
Additional info
Gene ID 4599
Other Names Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, IFI-78K, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, Interferon-induced GTP-binding protein Mx1, N-terminally processed, MX1
Target/Specificity This MX1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 617-646 amino acids from human MX1.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MX1
Function Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
Cellular Location Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845)
Research Areas
Visualizing infection spread: dual-color fluorescent reporting of virus-host interactions.
Author : Swick A1, Baltes A, Yin J.
Biotechnol Bioeng. 2014 Jun;111(6):1200-9. doi: 10.1002/bit.25170. Epub 2013 Dec 28.
24338628
Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway Independence.
Author : Voigt EA1, Yin J.
J Interferon Cytokine Res. 2015 May 4. [Epub ahead of print]
25938799

BACKGROUND

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.

REFERENCES

Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
van der Voort, L.F., et al. Neurology 75(14):1228-1233(2010)
Ching, J.C., et al. J. Infect. Dis. 201(12):1899-1908(2010)
Zhijian, Y., et al. Virol. J. 7, 278 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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