注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   精选抗体   >   CDKN1C Antibody (Ascites)   

CDKN1C Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - CDKN1C Antibody (Ascites) AM2072a
    CDKN1C Antibody (Cat. #AM2072a) western blot analysis in HL-60 cell line lysates (35μg/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow).
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P49918
Other Accession NP_000067.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 522CT9.5.1
Calculated MW 32177 Da
Additional info
Gene ID 1028
Other Names Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2
Target/Specificity This CDKN1C antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from human CDKN1C.
Dilution WB~~1:500~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDKN1C Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN1C
Synonyms KIP2
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
Cellular Location Nucleus.
Tissue Location Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Research Areas

BACKGROUND

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

REFERENCES

O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)
Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :
Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

FeedBack

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-88856768 tech-china@abcepta.com.


我要评价