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>   首页   >   产品   >   一抗   >   癌症   >   HPRT1 Antibody(Ascites)   

HPRT1 Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - HPRT1 Antibody(Ascites) AM2086a
    HPRT1 Antibody (Cat. #AM2086a) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the HPRT1 antibody detected the HPRT1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P00492
Other Accession Q6LDD9, NP_000185.1
Reactivity Human
Predicted Monkey
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 571CT1.3.4
Calculated MW 24579 Da
Additional info
Gene ID 3251
Other Names Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase, HPRT1, HPRT
Target/Specificity This HPRT1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human HPRT1.
Dilution WB~~1:500~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHPRT1 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPRT1
Synonyms HPRT
Function Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Cellular Location Cytoplasm.
Research Areas

BACKGROUND

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.

REFERENCES

Garcia, M.G., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 301-305 (2010) :
Torres, R.J., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 295-300 (2010) :
Yamada, Y., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 291-294 (2010) :
Zampieri, M., et al. Mech. Ageing Dev. 131(2):89-95(2010)
Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)

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