|Application ||WB, E|
|Calculated MW||17628 Da|
|Other Names||Interleukin-2, IL-2, T-cell growth factor, TCGF, Aldesleukin, IL2|
|Target/Specificity||This IL2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 50-77 amino acids from the Central region of human IL2.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL2 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Zhu, P., et al. J. Immunol. 185(9):5140-5149(2010)
Muller, T., et al. Scand. J. Immunol. 72(4):365-371(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Horowitz, A., et al. J. Immunol. 185(5):2808-2818(2010)
Wu, Z., et al. J Mol Cell Biol 2(4):217-222(2010)