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MVP Antibody (N-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - MVP Antibody (N-term) (Ascites) AM2146a
    MVP Antibody (N-term)(Ascites)(Cat. #AM2146a) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the MVP antibody detected the MVP protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q14764
Other Accession Q62667, Q9EQK5, Q3SYU9, NP_005106.2
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 599CT2.4.1
Calculated MW 99327 Da
Additional info
Gene ID 9961
Other Names Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Target/Specificity This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP.
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMVP Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVP
Synonyms LRP
Function Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Cellular Location Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665)
Tissue Location Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
Research Areas

BACKGROUND

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

REFERENCES

Li, J., et al. Lung Cancer 69(1):116-122(2010)
Liang, P., et al. Biochem. Cell Biol. 88(3):445-450(2010)
An, H.J., et al. Cell Biochem. Funct. 27(5):289-295(2009)
Li, L., et al. Zhonghua Zhong Liu Za Zhi 31(3):199-202(2009)
Lara, P.C., et al. Radiat Oncol 4, 29 (2009) :

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