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FOLR2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - FOLR2 Antibody AM8660b
    All lanes : Anti-FOLR2 Antibody at 1:1000-1:2000 dilution Lane 1: Human spleen lysate Lane 2: Human placenta lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14207
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG2b,κ
Clone Names 1905CT501.41.76
Calculated MW 29280 Da
Additional info
Gene ID 2350
Other Names Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2
Target/Specificity This FOLR2 antibody is generated from a mouse immunized with a recombiant protein from human FOLR2.
Dilution WB~~1:1000-1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOLR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOLR2
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Tissue Location Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues
Research Areas

BACKGROUND

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

REFERENCES

Page S.T.,et al.J. Mol. Biol. 229:1175-1183(1993).
Ratnam M.,et al.Biochemistry 28:8249-8254(1989).
Sadasivan E.,et al.J. Biol. Chem. 269:4725-4735(1994).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Freisheim J.H.,et al.Adv. Enzyme Regul. 29:13-26(1989).

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