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PEX1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PEX1 Antibody (Center) AP10181c
    PEX1 Antibody (Center) (Cat. #AP10181c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PEX1 antibody detected the PEX1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O43933
Other Accession NP_000457.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 142867 Da
Additional info
Gene ID 5189
Other Names Peroxisome biogenesis factor 1, Peroxin-1, Peroxisome biogenesis disorder protein 1, PEX1
Target/Specificity This PEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-628 amino acids from the Central region of human PEX1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPEX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEX1
Function Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
Cellular Location Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes
Research Areas

BACKGROUND

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.

REFERENCES

Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Yik, W.Y., et al. Hum. Mutat. 30 (3), E467-E480 (2009) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Tamura, S., et al. J. Biol. Chem. 281(38):27693-27704(2006)

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