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LY6G6C Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - LY6G6C Antibody (C-term) AP10539b
    LY6G6C Antibody (C-term) (Cat. #AP10539b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LY6G6C antibody detected the LY6G6C protein (arrow).
  • 14 - LY6G6C Antibody (C-term) AP10539b
    LY6G6C antibody (C-term) (Cat. #AP10539b) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph node followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LY6G6C antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession O95867
Other Accession NP_079537.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 13821 Da
Additional info
Gene ID 80740
Other Names Lymphocyte antigen 6 complex locus protein G6c, LY6G6C, C6orf24, G6C, NG24
Target/Specificity This LY6G6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the C-terminal region of human LY6G6C.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLY6G6C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LY6G6C
Synonyms C6orf24, G6C, NG24
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Tissue Location Highly expressed at the leading edges of cells, on filopodia.
Research Areas

BACKGROUND

LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).

REFERENCES

Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Xie, T., et al. Genome Res. 13(12):2621-2636(2003)
Mallya, M., et al. Genomics 80(1):113-123(2002)

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