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EDN3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - EDN3 Antibody (C-term) AP11222b
    EDN3 Antibody (C-term) (Cat. #AP11222b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the EDN3 antibody detected the EDN3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14138
Other Accession Q03229, NP_000105
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25454 Da
Additional info
Gene ID 1908
Other Names Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3
Target/Specificity This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEDN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDN3
Function Endothelins are endothelium-derived vasoconstrictor peptides.
Cellular Location Secreted.
Tissue Location Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)
Sanchez-Mejias, A., et al. Genet. Med. 12(1):39-43(2010)
Broasca, V., et al. Rom J Morphol Embryol 51(2):283-288(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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