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LZP Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - LZP Antibody AP11447a
    Western blot analysis of LZP (arrow) using rabbit polyclonal LZP Antibody (Cat. #AP11447a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LZP gene.
  • 1 - LZP Antibody AP11447a
    LZP Antibody (Cat. #AP11447a) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the LZP antibody detected the LZP protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8WWZ8
Other Accession NP_689848.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Other Names Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein, OIT3, LZP
Target/Specificity This OIT3 antibody is generated from rabbits immunized with a Gst fusion protein from human OIT3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLZP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OIT3
Synonyms LZP
Function May be involved in hepatocellular function and development.
Cellular Location Nucleus envelope. Note=Can be secreted into blood
Tissue Location Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines. EMBL; AY013707; AAG40096.2; -; mRNA EMBL; AY358339; AAQ88705.1; -; mRNA EMBL; AK096435; BAC04788.1; -; mRNA EMBL; BC126440; AAI26441.1; -; mRNA CCDS; CCDS7318.1; -. [Q8WWZ8-1] RefSeq; NP_689848.1; NM_152635.2. [Q8WWZ8-1] UniGene; Hs.8366; - ProteinModelPortal; Q8WWZ8; - SMR; Q8WWZ8; - BioGrid; 128002; 1 IntAct; Q8WWZ8; 10 GlyConnect; 1964; - iPTMnet; Q8WWZ8; - PhosphoSitePlus; Q8WWZ8; - BioMuta; OIT3; - DMDM; 74730985; - PaxDb; Q8WWZ8; - PeptideAtlas; Q8WWZ8; - PRIDE; Q8WWZ8; - ProteomicsDB; 74973; - ProteomicsDB; 74974; -. [Q8WWZ8-2] DNASU; 170392; - Ensembl; ENST00000334011; ENSP00000333900; ENSG00000138315. [Q8WWZ8-1] Ensembl; ENST00000622652; ENSP00000479787; ENSG00000138315. [Q8WWZ8-2] GeneID; 170392; - KEGG; hsa:170392; - UCSC; uc001jte.2; human. [Q8WWZ8-1] CTD; 170392; - DisGeNET; 170392; - EuPathDB; HostDB:ENSG00000138315.12; - GeneCards; OIT3; - HGNC; HGNC:29953; OIT3 MIM; 609330; gene neXtProt; NX_Q8WWZ8; - OpenTargets; ENSG00000138315; - PharmGKB; PA142671231; - eggNOG; ENOG410IHDE; Eukaryota eggNOG; ENOG4110JPJ; LUCA GeneTree; ENSGT00940000157851; - HOGENOM; HOG000115262; - HOVERGEN; HBG097756; - InParanoid; Q8WWZ8; - OMA; IMSRNHG; - OrthoDB; 319810at2759; - PhylomeDB; Q8WWZ8; - TreeFam; TF330284; - ChiTaRS; OIT3; human GenomeRNAi; 170392; - PRO; PR:Q8WWZ8; - Proteomes; UP000005640; Chromosome 10 Bgee; ENSG00000138315; Expressed in 41 organ(s), highest expression level in liver Genevisible; Q8WWZ8; HS GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:1903118; P:urate homeostasis; IEA:Ensembl InterPro; IPR001881; EGF-like_Ca-bd_dom InterPro; IPR000742; EGF-like_dom InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site InterPro; IPR018097; EGF_Ca-bd_CS InterPro; IPR001507; ZP_dom Pfam; PF00100; Zona_pellucida; 1 PRINTS; PR00023; ZPELLUCIDA SMART; SM00181; EGF; 3 SMART; SM00179; EGF_CA; 2 SMART; SM00241; ZP; 1 PROSITE; PS00010; ASX_HYDROXYL; 1 PROSITE; PS01187; EGF_CA; 1 PROSITE; PS51034; ZP_2; 1 1: Evidence at protein level; Alternative splicing; Calcium; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Nucleus; Polymorphism; Reference proteome; Signal SIGNAL 1 22 CHAIN 23 545 Oncoprotein-induced transcript 3 protein /FTId=PRO_0000298931 DOMAIN 182 222 EGF-like; calcium-binding. DOMAIN 261 516 ZP. {ECO:0000255|PROSITE- ProRule:PRU00375} CARBOHYD 89 89 N-linked (GlcNAc...) asparagine CARBOHYD 116 116 N-linked (GlcNAc...) asparagine CARBOHYD 291 291 N-linked (GlcNAc...) asparagine CARBOHYD 299 299 N-linked (GlcNAc...) asparagine DISULFID 186 197 DISULFID 193 206 DISULFID 208 221 VAR_SEQ 318 321 VVND -> LCFR (in isoform 2) /FTId=VSP_027482 VAR_SEQ 322 545 Missing (in isoform 2) /FTId=VSP_027483 VARIANT 237 237 S -> P (in dbSNP:rs35089256) /FTId=VAR_034742 SEQUENCE 545 AA; 60022 MW; E4BDE126213484B0 CRC64; MPPFLLLTCL FITGTSVSPV ALDPCSAYIS LNEPWRNTDH QLDESQGPPL CDNHVNGEWY HFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEGDGIV QRQACASFNG NCCLWNTTVE VKACPGGYYV YRLTKPSVCF HVYCGHFYDI CDEDCHGSCS DTSECTCAPG TVLGPDRQTC FDENECEQNN GGCSEICVNL KNSYRCECGV GRVLRSDGKT CEDVEGCHNN NGGCSHSCLG SEKGYQCECP RGLVLSEDNH TCQVPVLCKS NAIEVNIPRE LVGGLELFLT NTSCRGVSNG THVNILFSLK TCGTVVDVVN DKIVASNLVT GLPKQTPGSS GDFIIRTSKL LIPVTCEFPR LYTISEGYVP NLRNSPLEIM SRNHGIFPFT LEIFKDNEFE EPYREALPTL KLRDSLYFGI EPVVHVSGLE SLVESCFATP TSKIDEVLKY YLIRDGCVSD DSVKQYTSRD HLAKHFQVPV FKFVGKDHKE VFLHCRVLVC GVLDERSRCA QGCHRRMRRG AGGEDSAGLQ GQTLTGGPIR IDWED
Research Areas

BACKGROUND

May be involved in hepatocellular function and development.

REFERENCES

Shen, H.L., et al. Mol. Cell. Biochem. 321 (1-2), 73-83 (2009) :
Yang, H., et al. FEBS Lett. 578(3):236-238(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Xu, Z.G., et al. Hepatology 38(3):735-744(2003)

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