癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LILRA5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | A6NI73 |
| Other Accession | NP_871715.1, NP_067073.1, NP_871714.1, NP_870994.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32755 Da |
| Antigen Region | 56-85 aa |
| Gene ID | 353514 |
|---|---|
| Other Names | Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9, CD85f, LILRA5, ILT11, LILRB7, LIR9 |
| Target/Specificity | This LILRA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human LILRA5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LILRA5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LILRA5 |
|---|---|
| Synonyms | ILT11, LILRB7, LIR9 |
| Function | May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B- cells or natural killer (NK) cells (at protein level) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].
REFERENCES
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)
Shiroishi, M., et al. J. Biol. Chem. 281(28):19536-19544(2006)
Borges, L., et al. Blood 101(4):1484-1486(2003)
Wende, H., et al. Immunogenetics 51 (8-9), 703-713 (2000) :
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