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TGFB1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TGFB1 Antibody (N-term) AP12348A
    All lanes : Anti-TGFB1 Antibody (N-term) at 1:2000 dilution Lane 1: HepG2 whole cell lysate Lane 2: K562 whole cell lysate Lane 3: Raji whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01137
Other Accession P17246, P07200, P04202, P18341, NP_000651.3
Reactivity Human, Mouse
Predicted Rat, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 7040
Other Names Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
Target/Specificity This TGFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human TGFB1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGFB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFB1 (HGNC:11766)
Synonyms TGFB
Function Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Cellular Location Latency-associated peptide: Secreted, extracellular space, extracellular matrix
Tissue Location Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
Research Areas
Identification and analysis of key genes associated with ulcerative colitis based on DNA microarray data.
Author : Song R1,Li Y,Hao W,Wang B,Yang L,Xu F.
Medicine (Baltimore). 2018 May;97(21):e10658. doi: 10.1097/MD.0000000000010658.
29794741
CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner.
Author : Ren Y1, Du C1, Yan L1, Wei J1, Wu H1, Shi Y1, Duan H1.
Drug Des Devel Ther. 2015 Jul 31;9:4155-71. doi: 10.2147/DDDT.S86748. eCollection 2015.
26257513

BACKGROUND

TGFB1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

REFERENCES

Perez, A.B., et al. Hum. Immunol. 71(11):1135-1140(2010) Xu, Z., et al. Biochem. Biophys. Res. Commun. 401(3):376-381(2010) Bran, G.M., et al. Anticancer Res. 30(9):3459-3463(2010) Zauli, G., et al. Blood 80(12):3036-3043(1992) Wrana, J.L., et al. Cell 71(6):1003-1014(1992)

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