|Application ||WB, IHC-P, E|
|Other Names||Prostate stem cell antigen, PSCA|
|Target/Specificity||This PSCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human PSCA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSCA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.|
Provided below are standard protocols that you may find useful for product applications.
PSCA is a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. It is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas.
Zhigang,Z., Prostate 68 (2), 190-199 (2008)
Zhigang,Z., Prostate 67 (11), 1143-1151 (2007)