- 文献引用 : 1
|Application ||IF, WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||56381 Da|
|Other Names||Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM|
|Target/Specificity||This ALDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human ALDH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
Author : Duan Y1, Gao Y2, Zhang J1, Chen Y1, Jiang Y1, Ji J1, Zhang J1, Chen X1, Yang Q1, Su L1, Zhang J1, Liu B1, Zhu Z3
Free Radic Biol Med. 2016 Feb 4. pii: S0891-5849(16)00044-7. doi: 10.1016/j.freeradbiomed.2016.02.001. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.
Guo,Y.M., World J. Gastroenterol. 14 (9), 1444-1449 (2008) Chen,L., PLoS Med. 5 (3), E52 (2008) Teeguarden,J.G., Inhal Toxicol 20 (4), 375-390 (2008) Yoshida,A., Pharmacogenetics 2 (4), 139-147 (1992)