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LAMP3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
E
Primary Accession Q9UQV4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 27074
Other Names Lysosome-associated membrane glycoprotein 3, LAMP-3, Lysosomal-associated membrane protein 3, DC-lysosome-associated membrane glycoprotein, DC LAMP, Protein TSC403, CD208, LAMP3, DCLAMP, TSC403
Target/Specificity This LAMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human LAMP3.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLAMP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMP3
Synonyms DCLAMP, TSC403
Function May play a role in dendritic cell function and in adaptive immunity.
Cellular Location Lysosome membrane; Single- pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752) Detected on lysosomes in mature dendritic cells (PubMed:9768752)
Tissue Location Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level) Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.
Research Areas
The potential role of lysosome-associated membrane protein 3 (LAMP3) on cardiac remodelling.
Author : Jiang DS1, Yi X2, Huo B1, Liu XX1, Li R1, Zhu XH1, Wei X1.
Am J Transl Res. 2016 Jan 15;8(1):37-48. eCollection 2016.
27069538
Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.
Author : Nagelkerke A, Mujcic H, Bussink J, Wouters BG, van Laarhoven HW, Sweep FC, Span PN.
Cancer. 2011 Aug 15;117(16):3670-81. doi: 10.1002/cncr.25938. Epub 2011 Feb 11.
21319150

BACKGROUND

LAMP3 is a member of a family of membrane glycoproteins. It may change lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells.

REFERENCES

References for protein:
1.Elliott,B., Clin. Cancer Res. 13 (13), 3825-3830 (2007)
2.Zhu,L.C., Hum. Pathol. 38 (2), 260-268 (2007)
3.Arruda,L.B., J. Immunol. 177 (4), 2265-2275 (2006)
References for U251 cell line:
1. Westermark B.; Pontén J.; Hugosson R. (1973).” Determinants for the establishment of permanent tissue culture lines from human gliomas”. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449].
2. Pontén, J.,Westermark B. (1978).” Properties of Human Malignant Glioma Cells in Vitro”. Medical Biology 56: 184-193.[PMID: 359950].
3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). “Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent”. Neuro Oncol. 12(5): 473–481.[ PMID: 20406898].

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