注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   癌症   >   AMOT Antibody (Center S305)   

AMOT Antibody (Center S305)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - AMOT Antibody (Center S305) AP19247c
    All lanes : Anti-AMOT Antibody (Center S305) at 1:500-1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 118 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q4VCS5
Other Accession Q8VHG2, NP_001106962.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 118085 Da
Additional info
Gene ID 154796
Other Names Angiomotin, AMOT, KIAA1071
Target/Specificity This AMOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-312 amino acids from the Central region of human AMOT.
Dilution WB~~1:500-1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMOT Antibody (Center S305) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMOT
Synonyms KIAA1071
Function Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Cellular Location Cell junction, tight junction. Note=Localized on the cell surface May act as a transmembrane protein
Tissue Location Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Research Areas

BACKGROUND

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Heller, B., et al. J. Biol. Chem. 285(16):12308-12320(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gagne, V., et al. Cell Motil. Cytoskeleton 66(9):754-768(2009)
Zheng, Y., et al. Circ. Res. 105(3):260-270(2009)

FeedBack

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-88856768 tech-china@abcepta.com.


我要评价