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TCF7 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TCF7 Antibody (N-term) AP1951a
    Western blot analysis of anti-TCF7 Pab (Cat. #AP1951a) in mouse heart tissue lysate (35ug/lane). TCF7(arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P36402
Other Accession Q00417, Q86WR9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41642 Da
Additional info
Gene ID 6932
Other Names Transcription factor 7, TCF-7, T-cell-specific transcription factor 1, T-cell factor 1, TCF-1, TCF7, TCF1
Target/Specificity This TCF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-36 amino acids from the N-terminal region of human TCF7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCF7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCF7
Synonyms TCF1
Function Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Cellular Location Nucleus.
Tissue Location Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium
Research Areas
Long non-coding RNA lncTCF7 activates the Wnt/β-catenin pathway to promote metastasis and invasion in colorectal cancer.
Author : Li T1,Zhu J1,Wang X1,Chen G1,Sun L1,Zuo S1,Zhang J1,Chen S1,Ma J1,Yao Z1,Zheng Y1,Chen Z1,Liu Y1,Wang P1.
Oncol Lett. 2017 Dec;14(6):7384-7390. doi: 10.3892/ol.2017.7154. Epub 2017 Oct 9.
29344178

BACKGROUND

The T cell specific transcription factor TCF7 activates genes involved in immune regulation and thymocyte differentiation, and is a candidate locus for genetic susceptibility to type 1 diabetes.

REFERENCES

Smit, L., et al., J. Biol. Chem. 279(17):17232-17240 (2004).
Ioannidis, V., et al., J. Immunol. 171(2):769-775 (2003).
Noble, J.A., et al., Diabetes 52(6):1579-1582 (2003).
Batlle, E., et al., Cell 111(2):251-263 (2002).
van de Wetering, M., et al., J. Biol. Chem. 267(12):8530-8536 (1992).

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