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Dcr-1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Dcr-1 Antibody (Center) AP1961c
    Western blot analysis of Dcr-1 antibody (Center) (Cat. #AP1961c) in CEM cell line lysates (35ug/lane). Dcr-1 (arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P34529
Reactivity C.Elegans
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 176138
Other Names Endoribonuclease dcr-1, 3126-, dcr-1
Target/Specificity This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids from the Central region of human Dcr-1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDcr-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name dcr-1 {ECO:0000303|PubMed:11641272}
Function Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272).
Research Areas

BACKGROUND

The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.

REFERENCES

Duchaine TF, et al. 2006. Cell 124:343-354.
Denli AM, et al. 2004. Nature 432:231-235.
Tabara H, et al. 2002. Cell 109:861-871.
Grishok A, et al. 2001. Cell 106:23-34.
Knight SW, et al. 2001. Science 293:2269-2271.

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