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Rex1 (ZFP42) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Rex1 (ZFP42) Antibody (N-term) AP2051A
    Western blot analysis of Rex1 (ZFP42) antibody (N-term) (Cat.# AP2051a) in mouse lung tissue lysates (35ug/lane). Rex1 (arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96MM3
Other Accession Q8WXE2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34802 Da
Additional info
Gene ID 132625
Other Names Zinc finger protein 42 homolog, Zfp-42, Reduced expression protein 1, REX-1, hREX-1, Zinc finger protein 754, ZFP42, REX1, ZNF754
Target/Specificity This Rex1 (ZFP42) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Rex1 (ZFP42).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRex1 (ZFP42) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFP42
Synonyms REX1, ZNF754
Function Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines
Research Areas
Progesterone-dependent deoxyribonucleic acid looping between RUSH/SMARCA3 and Egr-1 mediates repression by c-Rel.
Author : Hewetson A, Chilton BS.
Mol Endocrinol. 2008 Apr;22(4):813-22. doi: 10.1210/me.2007-0432. Epub 2008 Jan 3.
18174357

BACKGROUND

Zinc finger proteins have regions (zinc finger domains) consisting of cysteines and histidines or cysteines alone which can form a tetrahedral complex around a Zinc ion. Zinc finger represent a class of DNA-binding proteins, act as transcriptional regulators of other genes. These multifunctional transcription factors exhibits control on a large number of cellular genes by binding to sites overlapping the transcription start site and plays an important role in development and differentiation. Hromas et al. in an effort to identify activators of the genetic cascade in hemopoietic differentiation probed a human myeloid cDNA library. ZNF42 may be a regulator of transcriptional events during hemopoietic development.

REFERENCES

Hromas R, et al. J. Biol. Chem. 1991. 266: 14183-14187.
Morris J, et al. Blood 1995. 86: 3640-3647.

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