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MME Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 14 - MME Antibody (Center) AP20698c
    Immunohistochemical analysis of paraffin-embedded H. skeletal muscle section using MME Antibody (Center)(Cat#AP20698c). AP20698c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 14 - MME Antibody (Center) AP20698c
    Immunohistochemical analysis of paraffin-embedded H. kidney section using MME Antibody (Center)(Cat#AP20698c). AP20698c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • 1 - MME Antibody (Center) AP20698c
    Western blot analysis of lysates from LNCaP cell line , mouse kidney, rat kidney tissue lysate(from left to right), using MME Antibody (Center)(Cat. #AP20698c). AP20698c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P08473
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 85514 Da
Additional info
Gene ID 4311
Other Names Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
Target/Specificity This MME antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 492-525 amino acids from the Central region of human MME.
Dilution IHC-P~~1:25
WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMME Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MME
Synonyms EPN
Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Cellular Location Cell membrane; Single-pass type II membrane protein
Research Areas

BACKGROUND

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers.

REFERENCES

Letarte M.,et al.J. Exp. Med. 168:1247-1253(1988).
Shipp M.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4819-4823(1988).
D'Adamio L.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7103-7107(1989).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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