|Application ||WB, E|
|Other Accession||O02811, O08662|
|Other Names||Phosphatidylinositol 4-kinase alpha, PI4-kinase alpha, PI4K-alpha, PtdIns-4-kinase alpha, 188.8.131.52, PI4KA, PIK4, PIK4CA|
|Target/Specificity||This PI4KA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1388-1422 amino acids from the Central region of human PI4KA.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PI4KA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.|
|Cellular Location||Cytoplasm. Cell membrane Note=Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899) Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530).|
|Tissue Location||Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.|
Provided below are standard protocols that you may find useful for product applications.
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.
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Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).