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IFI27 Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IFI27 Antibody (C-Term) AP22279b
    Anti-IFI27 Antibody (C-Term) at 1:500 dilution + Human spleen lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 11 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P40305
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 11542 Da
Additional info
Gene ID 3429
Other Names Interferon alpha-inducible protein 27, mitochondrial, p27, Interferon alpha-induced 11.5 kDa protein, Interferon-stimulated gene 12a protein, ISG12(a), IFI27
Target/Specificity This IFI27 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 72-106 amino acids from human IFI27.
Dilution WB~~1:500
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFI27 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFI27 (HGNC:5397)
Function Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon- induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).
Cellular Location Mitochondrion membrane; Multi- pass membrane protein. Nucleus inner membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported
Research Areas

BACKGROUND

Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.

REFERENCES

Rasmussen U.B.,et al.Cancer Res. 53:4096-4101(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Parker N.,et al.BMC Genomics 5:8-8(2004).
Rosebeck S.,et al.Apoptosis 13:562-572(2008).

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