THBS1 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, E |
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Primary Accession | P07996 |
Other Accession | Q28178 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 129383 Da |
Gene ID | 7057 |
---|---|
Other Names | Thrombospondin-1, THBS1, TSP, TSP1 |
Target/Specificity | This THBS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 820-854 amino acids from human THBS1. |
Dilution | WB~~1:2000 |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | THBS1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | THBS1 |
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Synonyms | TSP, TSP1 |
Function | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). |
Cellular Location | Secreted. Cell surface. Secreted, extracellular space, extracellular matrix Endoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993) Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:6341993, ECO:0000269|PubMed:6777381} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
REFERENCES
Lawler J.,et al.J. Cell Biol. 103:1635-1648(1986).
Hennessy S.W.,et al.J. Cell Biol. 108:729-736(1989).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).

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