|Application ||WB, E|
|Calculated MW||26596 Da|
|Other Names||C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2, CLEC1B, CLEC2|
|Target/Specificity||This CLEC1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 44-78 amino acids from the human region of human CLEC1B.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC1B Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.|
Provided below are standard protocols that you may find useful for product applications.
Colonna M.,et al.Eur. J. Immunol. 30:697-704(2000).
Chaipan C.,et al.J. Virol. 80:8951-8960(2006).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Scherer S.E.,et al.Nature 440:346-351(2006).
Suzuki-Inoue K.,et al.Blood 107:542-549(2006).