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phospho-Twist1-Y103 antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 6 -  phospho-Twist1-Y103 antibody AP22382a
    Dot blot analysis of Phospho-Twist 1-Y103 Phospho-specific Pab (AP22382a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
DB, E
Primary Accession Q15672
Reactivity Human
Host Rabbit
Clonality Polyclonal
Additional info
Gene ID 7291
Other Names Twist-related protein 1, Class A basic helix-loop-helix protein 38, bHLHa38, H-twist, TWIST1, BHLHA38, TWIST
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions phospho-Twist1-Y103 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TWIST1
Synonyms BHLHA38, TWIST
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
Cellular Location Nucleus.
Tissue Location Subset of mesodermal cells.
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