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KLF4 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - KLF4 Antibody (N-term) AP2725d
    KLF4 Antibody (N-term) (Cat. #AP2725d) western blot analysis in Hela,MCF-7,SW480 cell line lysates (35ug/lane).This demonstrates the KLF4 antibody detected the KLF4 protein (arrow).
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  • 文献引用 : 4
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  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O43474
Other Accession NP_004226
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54671 Da
Additional info
Gene ID 9314
Other Names Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF
Target/Specificity This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-53 amino acids from the N-terminal region of human KLF4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLF4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF4
Synonyms EZF, GKLF
Function Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Cellular Location Nucleus.
Research Areas
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4.
Author : Xu L1,Sun H2,Zhang M2,Jiang Y2,Zhang C2,Zhou J2,Ding L2,Hu Y3,Yan G4.
Mol Cell Endocrinol. 2017 May 28. pii: S0303-7207(17)30299-X. doi: 10.1016/j.mce.2017.05.030. [Epub ahead of print]
28564582
MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4.
Author : Yan C1, Yu J2, Liu Y3, Kang W1, Ma Z1, Zhou L1.
Biochem Biophys Res Commun. 2015 Oct 12. pii: S0006-291X(15)30744-0. doi: 10.1016/j.bbrc.2015.10.044. [Epub ahead of print]
26471298
Pluripotent stem cells derived from mouse and human white mature adipocytes.
Author : Jumabay M1, Abdmaulen R, Ly A, Cubberly MR, Shahmirian LJ, Heydarkhan-Hagvall S, Dumesic DA, Yao Y, Boström KI.
Stem Cells Transl Med. 2014 Feb;3(2):161-71. doi: 10.5966/sctm.2013-0107. Epub 2014 Jan 6.
24396033
Regulation of the human HBA genes by KLF4 in erythroid cell lines.
Author : Marini MG, Porcu L, Asunis I, Loi MG, Ristaldi MS, Porcu S, Ikuta T, Cao A, Moi P.
Br J Haematol. 2010 Jun;149(5):748-58. doi: 10.1111/j.1365-2141.2010.08130.x. Epub 2010 Mar 15.
20331458

BACKGROUND

Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.

REFERENCES

Alder,J.K., J. Immunol. 180 (8), 5645-5652 (2008)
Natesampillai,S., Am. J. Physiol. Endocrinol. Metab. 294 (2), E385-E391 (2008)
Evans,P.M., J. Biol. Chem. 282 (47), 33994-34002 (2007)
Behr,R., Mol. Hum. Reprod. 13 (11), 815-820 (2007)

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