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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Phospho-AMOT(S1041) Antibody   

Phospho-AMOT(S1041) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 6 - Phospho-AMOT(S1041) Antibody AP3776a
    Dot blot analysis of Phospho-AMOT-S1041 Antibody Phospho-specific Pab (Cat. #AP3776a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
DB, E
Primary Accession Q4VCS5
Other Accession NP_001106962.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 118085 Da
Additional info
Gene ID 154796
Other Names Angiomotin, AMOT, KIAA1071
Target/Specificity This AMOT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1041 of human AMOT.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-AMOT(S1041) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMOT
Synonyms KIAA1071
Function Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Cellular Location Cell junction, tight junction. Note=Localized on the cell surface May act as a transmembrane protein
Tissue Location Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Research Areas

BACKGROUND

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Heller, B., et al. J. Biol. Chem. 285(16):12308-12320(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gagne, V., et al. Cell Motil. Cytoskeleton 66(9):754-768(2009)
Zheng, Y., et al. Circ. Res. 105(3):260-270(2009)

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