|Application ||WB, IF, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||36 KDa|
|Other Names||PDZ and LIM domain protein 1, C-terminal LIM domain protein 1, Elfin, LIM domain protein CLP-36, PDLIM1, CLIM1, CLP36|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with actin stress fibers.|
|Tissue Location||Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes|
Provided below are standard protocols that you may find useful for product applications.
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.
Kotaka M.,et al.J. Cell. Biochem. 72:279-285(1999).
Bauer K.,et al.Blood 96:4236-4245(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).