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NECAB3 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NECAB3 Antibody AP50606
    Western blot analysis of lysates from human heart and skeletal muscle tissue lysate (from left to right),using NECAB3 Antibody(AP50606). AP50606 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 3 - NECAB3 Antibody AP50606
    Immunofluorescence analysis of A549 cells, using NECAB3 antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF
Primary Accession Q96P71
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Calculated MW 44,41,22 KDa
Additional info
Gene ID 63941
Other Names N-terminal EF-hand calcium-binding protein 3, Amyloid beta A4 protein-binding family A member 2-binding protein, Nek2-interacting protein 1, Neuronal calcium-binding protein 3, X11L-binding protein 51, NECAB3, APBA2BP, NIP1, SYTIP2, XB51
Dilution WB~~ 1:1000
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name NECAB3
Synonyms APBA2BP, NIP1, SYTIP2, XB51
Function Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.
Cellular Location Golgi apparatus
Tissue Location Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas
Research Areas

BACKGROUND

Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid.

REFERENCES

Sugita S.,et al.Neuroscience 112:51-63(2002).
Yoo J.C.,et al.Exp. Cell Res. 292:393-402(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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