|Application ||WB, IF|
|Calculated MW||44,41,22 KDa|
|Other Names||N-terminal EF-hand calcium-binding protein 3, Amyloid beta A4 protein-binding family A member 2-binding protein, Nek2-interacting protein 1, Neuronal calcium-binding protein 3, X11L-binding protein 51, NECAB3, APBA2BP, NIP1, SYTIP2, XB51|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||APBA2BP, NIP1, SYTIP2, XB51|
|Function||Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.|
|Cellular Location||Golgi apparatus|
|Tissue Location||Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas|
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Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid.
Sugita S.,et al.Neuroscience 112:51-63(2002).
Yoo J.C.,et al.Exp. Cell Res. 292:393-402(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.