注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   神经科学   >   SLC1A1 Antibody   

SLC1A1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SLC1A1 Antibody AP50729
    Western blot analysis of lysates from human liver tissue lysate,using SLC1A1 Antibody was diluted at 1:500 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P43005
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 57 KDa
Additional info
Gene ID 6505
Other Names Excitatory amino acid transporter 3, Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1, SLC1A1, EAAC1, EAAT3
Dilution WB~~ 1:500
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name SLC1A1
Synonyms EAAC1, EAAT3
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity).
Cellular Location Cell membrane; Multi- pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}
Tissue Location Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers)
Research Areas

BACKGROUND

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).

REFERENCES

Shashidharan P.,et al.Brain Res. 662:245-250(1994).
Kanai Y.,et al.J. Biol. Chem. 269:20599-20606(1994).
Arriza J.L.,et al.J. Neurosci. 14:5559-5569(1994).
Veenstra-VanderWeele J.,et al.Mol. Psychiatry 6:160-167(2001).
Yasuda-Kamatani Y.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.

FeedBack

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-88856768 tech-china@abcepta.com.


我要评价