|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat, Rabbit, Chicken, Guinea Pig, Dog|
|Calculated MW||51; [uniprot,origene,epi]56; KDa|
|Other Names||Fibrinogen beta chain, Fibrinopeptide B, Fibrinogen beta chain, FGB|
|Format||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce|
|Storage||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
|Function||Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.|
|Tissue Location||Detected in blood plasma (at protein level).|
Provided below are standard protocols that you may find useful for product applications.
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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Chung D.W.,et al.Adv. Exp. Med. Biol. 281:39-48(1990).
Chung D.W.,et al.(In) Liu C.Y., Chien S. (eds.);
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.