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Fibrinogen beta chain Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 3 - Fibrinogen beta chain Antibody AP50861
    Formalin-fixed and paraffin-embedded human lung carcinoma labeled with Anti-Fibrinogen beta chain Polyclonal Antibody, Unconjugated AP50861 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated used at 1:200 dilution for 40 minutes at 37°C.
  • 1 - Fibrinogen beta chain Antibody AP50861
    Western blot analysis of lysate from HepG2 cell line,using Fibrinogen beta chain Antibody(AP50861). AP50861 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • 2 - Fibrinogen beta chain Antibody AP50861
    Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer at 37℃ for 20 min;Incubation: Anti-Fibrinogen beta chain Polyclonal Antibody, Unconjugated 1:200, overnight at 4°C, followed by conjugation to the secondary antibodyand DAB staining.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF
Primary Accession P02675
Reactivity Human, Mouse, Rat, Rabbit, Chicken, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 51; [uniprot,origene,epi]56; KDa
Additional info
Gene ID 2244
Other Names Fibrinogen beta chain, Fibrinopeptide B, Fibrinogen beta chain, FGB
Dilution IF~~1/100~1/200
WB~~1/500
IHC~~1/100-1/500
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Protein Information
Name FGB
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted
Tissue Location Detected in blood plasma (at protein level).
Research Areas

BACKGROUND

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

REFERENCES

Chung D.W.,et al.Biochemistry 22:3244-3250(1983).
Chung D.W.,et al.Adv. Exp. Med. Biol. 281:39-48(1990).
Chung D.W.,et al.(In) Liu C.Y., Chien S. (eds.);
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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