C1R Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB |
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Primary Accession | P00736 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 80119 Da |
Gene ID | 715 |
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Other Names | Complement C1r subcomponent, Complement component 1 subcomponent r, Complement C1r subcomponent heavy chain, Complement C1r subcomponent light chain, C1R |
Target/Specificity | KLH conjugated synthetic peptide derived from human Complement C1R LC |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | C1R {ECO:0000303|PubMed:3021205, ECO:0000312|HGNC:HGNC:1246} |
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Function | Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:17996945, PubMed:19473974, PubMed:29449492). C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed:29449492, PubMed:34155115). Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R (PubMed:11445589, PubMed:11673533, PubMed:17996945, PubMed:20178990, PubMed:6254570, PubMed:6271784). Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway (PubMed:11445589, PubMed:11673533, PubMed:6271784). It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces (PubMed:28104818, PubMed:29311313, PubMed:29449492). |
Cellular Location | Secreted. Cell surface. Note=Recruited to the surface of pathogens by the C1Q subcomplex. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
REFERENCES
Leytus S.P.,et al.Biochemistry 25:4855-4863(1986).
Journet A.,et al.Biochem. J. 240:783-787(1986).
Nakagawa M.,et al.Ann. Hum. Genet. 67:207-215(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).

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