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RAB3GAP1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - RAB3GAP1 Antibody AP51827
    All lanes : Anti-RAB3GAP1 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 111 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q15042
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 111 KDa
Additional info
Gene ID 22930
Other Names Rab3 GTPase-activating protein catalytic subunit, RAB3 GTPase-activating protein 130 kDa subunit, Rab3-GAP p130, Rab3-GAP, RAB3GAP1, KIAA0066, RAB3GAP
Target/Specificity KLH conjugated synthetic peptide derived from human RAB3GAP1
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name RAB3GAP1
Synonyms KIAA0066, RAB3GAP
Function Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Cellular Location Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction
Tissue Location Ubiquitous..
Research Areas

BACKGROUND

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

REFERENCES

Nomura N.,et al.DNA Res. 1:223-229(1994).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Fukui K.,et al.J. Biol. Chem. 272:4655-4658(1997).
Oishi H.,et al.J. Biol. Chem. 273:34580-34585(1998).
Clabecq A.,et al.J. Biol. Chem. 275:31786-31791(2000).

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