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NUP98 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - NUP98 Antibody AP52748
    Western blot detection of NUP98 in Hela,Jurkat and MCF7 cell lysates using NUP98 mouse mAb (1:1000 diluted).Predicted band size: 98kDa.Observed band size: 98kDa.
  • 5 - NUP98 Antibody AP52748
    Immunoprecipitation analysis of Hela cell lysates using NUP98 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession P52948
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Calculated MW 98 KDa
Additional Information
Gene ID 4928
Other Names 96 kDa nucleoporin;98 kDa nucleoporin;ADAR2;ADIR2;GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup96;Nuclear pore complex protein Nup98 Nup96;Nucleoporin 98kD;nucleoporin 98kDa;Nucleoporin Nup96;Nucleoporin Nup98;NUP196;NUP96;Nup98;Nup98-Nup96;NUP98_HUMAN.
Dilution WB~~1:1000
IP~~1:500
Format Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50% glycerol
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name NUP98
Synonyms ADAR2
Function Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
Cellular Location Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134) Remains localized to the nuclear membrane after poliovirus (PV) infection (PubMed:11106761).
Research Areas

BACKGROUND

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.

REFERENCES

Borrow J.,et al.Nat. Genet. 12:159-167(1996).
Arai Y.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Fontoura B.M.A.,et al.J. Cell Biol. 144:1097-1112(1999).
Borrow J.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).

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