|Reactivity||Human, Mouse, Neisseria Gonorrhoeae|
|Calculated MW||45 KDa|
|Other Names||A X actin like protein;ACTB;ACTB_HUMAN;Actin;Actin cytoplasmic 1;Actx;b actin;b-actin;Beta cytoskeletal actin;Beta-actin;cytoplasmic 1;Melanoma X actin;N-terminally processed;PS1TP5 binding protein 1;PS1TP5BP1.|
|Format||Purified mouse monoclonal in PB(pH 7.4) containing with 0.02% sodium azide,50% glycerol and 1mg/ml BSA.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G- actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947).|
|Cellular Location||Cytoplasm, cytoskeleton Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
Provided below are standard protocols that you may find useful for product applications.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Ponte P.,et al.Nucleic Acids Res. 12:1687-1696(1984).
Nakajima-Iijima S.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6133-6137(1985).
Ohmori H.,et al.J. Cell Biol. 116:933-941(1992).
Hillier L.W.,et al.Nature 424:157-164(2003).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).