Anti-Toll-like Receptor 7 Antibody
Mouse Anti Human Monoclonal Antibody
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- 实验流程
- 背景知识
Application ![]()
| WB |
---|---|
Primary Accession | Q9NYK1 |
Other Accession | NM_016562 |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Immunogen | Purified recombinant human Toll-like Receptor protein fragments expressed in E.coli. |
Purification | Affinity purified |
Gene ID | 51284 |
---|---|
Other Names | PRO285; TLR 7; Tlr7; TLR7_HUMAN ; Toll like receptor 7 ; Toll-like receptor 7; UNQ248. |
Dilution | WB~~1:1000 |
Format | PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TLR7 |
---|---|
Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist {ECO:0000250|UniProtKB:P58681} |
Tissue Location | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-st

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