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NUR77 (NR4A1) Antibody (S351)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NUR77 (NR4A1) Antibody (S351) AP6289c
    All lanes : Anti-NUR77 (NR4A1) Antibody (S351) at 1:500 dilution Lane 1: Jurkat whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Human liver tissue lysate Lane 4: MCF-7 whole cell lysate Lane 5: Mouse brain tissue lysate Lane 6: NIH/3T3 whole cell lysate Lane 7: Rat brain tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 64 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P22736
Other Accession P22829, P12813
Reactivity Human, Mouse, Rat
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 3164
Other Names Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1
Target/Specificity This NUR77(NR4A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from human NUR77(NR4A1).
Dilution WB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNUR77 (NR4A1) Antibody (S351) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR4A1
Synonyms GFRP1, HMR, NAK1
Function Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Cellular Location Nucleus Cytoplasm. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27
Tissue Location Fetal muscle and adult liver, brain and thyroid
Research Areas
Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS).
Author : Geradts J1,2, Groth J3, Wu Y4, Jin G3.
Breast Cancer Res Treat. 2016 Jun 1. [Epub ahead of print]
27250000

BACKGROUND

NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. This protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.

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