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DSCR1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DSCR1 Antibody (Center) AP6315b
    The anti-DSCR1 Pab (Cat. #AP6315b) is used in Western blot to detect DSCR1 in endothelial cell lysate.
  • 1 - DSCR1 Antibody (Center) AP6315b
    Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4 deg C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P53805
Other Accession Q7Z555
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28079 Da
Additional info
Gene ID 1827
Other Names Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Target/Specificity This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human DSCR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDSCR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCAN1
Synonyms ADAPT78, CSP1, DSC1, DSCR1
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).
Tissue Location Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues
Research Areas

BACKGROUND

DSCR1 (calcipressin 1) interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Thr gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

REFERENCES

Minami, T., et al., J. Biol. Chem. 279(48):50537-50554 (2004). Yao, Y.G., et al., Biochem. Biophys. Res. Commun. 321(3):648-656 (2004). Michtalik, H.J., et al., Free Radic. Biol. Med. 37(4):454-462 (2004). Hesser, B.A., et al., Blood 104(1):149-158 (2004). Iizuka, M., et al., Biochem. Biophys. Res. Commun. 41(4):334-344 (2004).

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