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CDKN3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CDKN3 Antibody (C-term) AP7528b
    Anti-hCDKN3-A198 at 1:2000 dilution + HL-60 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - CDKN3 Antibody (C-term) AP7528b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession Q16667
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23805 Da
Additional info
Gene ID 1033
Other Names Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, CDKN3, CDI1, CIP2, KAP
Target/Specificity This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the C-terminal region of human CDKN3.
Dilution WB~~1:2000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDKN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN3
Synonyms CDI1, CIP2, KAP
Function May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Cellular Location Cytoplasm, perinuclear region
Research Areas

BACKGROUND

CDKN3 belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. The gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.

REFERENCES

Yeh, C.T., et al., Biochem. Biophys. Res. Commun. 305(2):311-314 (2003).
Yeh, C.T., et al., Cancer Res. 60(17):4697-4700 (2000).
Lee, S.W., et al., Mol. Cell. Biol. 20(5):1723-1732 (2000).
Poon, R.Y., et al., Science 270(5233):90-93 (1995).
Hannon, G.J., et al., Proc. Natl. Acad. Sci. U.S.A. 91(5):1731-1735 (1994).

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