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PKN beta Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PKN beta Antibody (C-term) AP7935a
    All lanes : Anti-PKN beta Antibody (C-term) at 1:500 dilution Lane 1: Hela whole cell lysate Lane 2: LNCaP whole cell lysate Lane 3: PC-3 whole cell lysate Lane 4: 293 whole cell lysate Lane 5: K562 whole cell lysate Lane 6: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 99 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q6P5Z2
Other Accession NP_037487
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 29941
Other Names Serine/threonine-protein kinase N3, Protein kinase PKN-beta, Protein-kinase C-related kinase 3, PKN3, PKNBETA
Target/Specificity This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.
Dilution WB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPKN beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PKN3
Synonyms PKNBETA
Function Contributes to invasiveness in malignant prostate cancer.
Cellular Location Nucleus. Cytoplasm, perinuclear region Note=Nuclear and perinuclear Golgi region
Tissue Location Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues
Research Areas

BACKGROUND

PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

REFERENCES

Oishi, K., et al., Biochem. Biophys. Res. Commun. 261(3):808-814 (1999).

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